We developed a protein research project for a one-semester biochemistry lecture class to enhance learning and more effectively train students to understand protein structure and function. During this semester-long process, students select a protein with known structure and then research its structure, sequence, and function. This project culminates with students preparing their own Jmol-enhanced Web site that both visualizes their chosen protein's structure and explains its function. All students were able to successfully produce a Web site regardless of prior experience. Compared with previous students who wrote a standard research paper, students involved in this project were more enthusiastic about biochemistry and ended the semester with a better appreciation of the connection between protein structure and protein function. (Contains 3 tables and 3 figures.)