The topics of nature, for example semiochemicals, are motivating topics, which can be used to teach organic chemistry at high school level. The history, classifications, a few important applications of semiochemicals, and an semiochemical that can be synthesized in the laboratory are presented. The laboratory synthesis is carried out through the well-known Fischer esterification reaction, which is easy to implement in a high school laboratory. Computer-based molecular modeling, based on free software, can be used for supporting the characterization of the synthesized molecule. This information can be used as orientation and motivating material for inquiry- and context-based high-school organic chemistry. (Contains 1 table, 2 figures, and 1 scheme.)