The creative application of low-cost, readily available materials and techniques promotes inclusion and provides accessibility in the classroom and laboratory for students who are blind or have low vision. Difficulties encountered by these students include operation of laboratory equipment, execution of ordinary laboratory procedures, and use of molecular structure models, all of which typically involve visual observations. The low-cost tools described in this article can help teachers provide more independent and rewarding laboratory and classroom experiences for these students. (Contains 5 figures.)