This case study reports the effects of musical interaction therapy (MIT) on the social and symbolic development of a young autistic girl. MIT fosters interpersonal contact and joint attention by synchronizing live music to adult-child interactions. Results offer preliminary evidence that MIT facilitates playful joint action formats that generalize…

A cluster analytic study was conducted to derive behaviorally homogeneous subtypes of pervasive developmental disorders (PDD) based on a range of behavioral symptoms that characterize autism. Analysis of data on 34 children with PDD, 27 of whom met criteria for autism, indicated 4 distinct groups differing on independent measures of social,…

Comparison of social initiations by 18 children with autism and 13 verbally matched children with mental retardation found autistic children's social initiations were more ritualized and the retarded children's were more playful. Autistic initiation to peers was unrelated to severity of autism, but was related to cognitive skills, whereas retarded…

Three nonspeaking children with autism who had used facilitated communication were evaluated with four experimentally controlled tasks. Findings suggested a generalized language deficit, rather than isolated word-finding or perceptual difficulties, and were consistent with previous studies revealing facilitator cuing. Questions are raised about…

Clozapine, a neuroleptic drug, was used to complete a 93-week double-blind crossover trial with a 40-year-old male having profound mental retardation and sensory impairments and displaying self-injurious behavior (SIB) patterns. Findings suggest that clozapine could be an effective pharmacological intervention for some cases of SIB. (DB)

This paper reviews the methodology in articles that have reported structural neuroimaging or neuropsychological data in adolescent patients with schizophrenia. Identification of methodological issues led to the finding that, at present, no conclusions can be made regarding the presence or absence of neuropsychologic dysfunction or structural…

This article presents a case report of a male child with Fragile X syndrome, typical autistic behavior, and cerebellar hypoplasia. Questions are raised concerning the possible role and importance of cerebellar abnormalities in relation to autistic symptoms. (DB)