This study compared the 2-year outcomes of 68 children diagnosed with autism or Asperger syndrome at age 6-8 years in terms of symptoms from the Autism Diagnostic Interview. Significant differences were seen in the domains of social interaction, communication, and repetitive activities, with the Asperger group demonstrating fewer and/or less…

The concurrent validity of the original and revised versions of the Leiter International Performance Scale was examined with 26 children (ages 4-16) with autism. Although the correlation between the two tests was high (.87), there were significant intra-individual discrepancies present in 10 cases, two of which were both large and clinically…

Two studies evaluated the PDD Behavior Inventory, (PDDBI), a rating scale designed to assess adaptive and maladaptive behaviors of children having a pervasive developmental disorder (PDD). It was concluded that the PDDBI is both reliable and valid and is useful in providing information not typically available in most instruments used to assess…

This study assessed the criterion-related validity of the PDD Behavior Inventory, a rating scale to evaluate the adaptive and maladaptive behaviors of children with pervasive developmental disorders. Good correlations with five other scales confirmed the scale's validity and suggest its value in assessing treatment-related changes in maladaptive…

This study compared 29 females with Turner syndrome and 21 females with fragile X syndrome (ages 6-22) on a videotaped role-play interaction with 34 females in a comparison group. Three of eight behavioral measures of social skills differentiated the participant groups. Fragile-X subjects required more time to initiate interactions and Turner…

This study assessed depression, anxiety, and relevant cognitions in 46 adults with borderline, mild, or moderate mental retardation. Consistent with research on other groups, self-reports of depression and anxiety were highly correlated and cognitions were strong predictors of negative affect. Hierarchical multiple regression analyses offered…

This prospective open-label study assessed the efficacy and tolerability of low-doze fluvoxamine in 14 children with pervasive developmental disorders (PDDs). Although there was no response for the group as a whole, eight subjects were considered at least partial responders in intent-to-treat analyses. Results suggest fluvoxamine can be beneficial…

This study examined Autism Diagnostic Interviews Revised (ADI-R) data for 69 autistic subjects from multiplex (MP) families (with more than one autistic member) and 88 autistic subjects from singleton (SP) families (with only one autistic member). Multivariate analysis revealed no differences between verbal or nonverbal MP and SP groups for ADI-R…

Plasma amino acid levels were measured in autistic (n=12), Asperger syndrome (n=11) patients, their parents and siblings. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenyalanine, asparagine, tyrosine, alanine, and lysine levels than age-matched controls. Results suggest dysregulated amino…

This study examined behavioral adjustment in 22 siblings of children with autism. Mothers rated these children as having more behavior problems and fewer prosocial behaviors than a normative sample. Analysis of variables revealed that male siblings and children younger than the autistic sibling engaged in fewer prosocial behaviors. Psychological…

This paper reports a clinical case of autism with a deletion on chromosome 2 in a young male with high functioning autism. The deletion seems to correspond with regions emerging from linkage studies. The paper proposes this chromosomal region as a possible candidate region in the search for autism genes. (Contains references.) (Author/DB)

Eight participants with Asperger syndrome (AS) (ages 10-41) were assessed in the following areas: the pragmatics of language and communication; verbal and visual memory; visual-spatial abilities; and bimanual motor skills. Results confirmed the close similarity in the neuropsychologic profiles of non-verbal learning disabilities syndrome and AS.…

A study evaluated a 7-month cognitive behavioral intervention for facilitating social-emotional understanding and social interaction of 15 high-functioning children (ages 8-17) with autism. Intervention focused on interpersonal problem solving, affective knowledge, and social interaction. After treatment, children were more likely to initiate…

A study compared the extent of agreement between parents and professional evaluators regarding the cognitive level of 41 children (ages 2-10) with autism. Significant differences were found. In addition, there was significant correlation between the level of agreement and cognitive functioning; agreement increased as the level of cognitive…

A study involving 30 Argentineans with autism evaluated the validity of the Autism Diagnostic Inventory-Telephone Screening in Spanish (ADI-TSS). The final version of the ADI-TSS could be assessed in 20 to 40 minutes and demonstrated a high validity, high interrater reliability, and high internal consistency. (Contains references.) (Author/CR)