The authors respond to a recent letter (Rossignol and Frye 2011) critical of their paper, "Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder" (Corrigan et al. 2011). Further considerations regarding the assessment of mitochondrial dysfunction in autism…

Genetic and epigenetic differences exist within monozygote twin-pairs and might be especially important in the expression of autism. Assuming phenotypic differences between monozygotic twins are due to environmental influences may lead to mistaken conclusions regarding the relative genetic and environmental contribution to autism risk.

This article discusses the problem of over-including individuals in the autism classification. It argues that clinicians are doing a disservice to individuals who are given the diagnosis of autism by considering the group as a whole, without further efforts to subtype based on something other than behavioral characteristics. (Contains references.)…

A reaction to Sowell's book raises issues about behaviorally based diagnoses, stressing that developmental disorders are behaviorally defined dimensions along a continuum with no crisp partition between normalcy and disorders. It sees developmental disorders as usually the expression of extremely complex, multigenic influences on brain…

This article comments on results of a study (EC 629 869) on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It discusses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains…

This article responds to comments (EC 629 869-70) on a study on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It addresses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains 6…

This article describes several features important in the success of using a behavioral model when treating individuals with autism and presents remaining issues to be addressed for improving treatment effectiveness. It urges future research to include strict empirical designs that allow for sound inferences regarding the parameters of treatment…

The sources of variability residing in the environment of individuals with autism and the implications for research studies are explored. Recommendations are provided for future research including research focusing on young children, on the methods needed to produce desirable outcomes, on relationships between behaviors, and on specific teaching…

This article outlines five achievements of the last 20 years that have had or have the potential for a significant effect on the communication of individuals with autism, including greater understanding of the development of language and nonverbal communication in individuals with autism. Suggestions for future research are offered. (Contains…

This article reviews research on social interventions that facilitate socialization in children with autism. It urges researchers to measure not only the social interaction skills of young people with autism but also the social exchanges of their typical peers in order to better structure teaching activities for youngsters with autism. (Contains…

This commentary discusses the wide acceptance of and the expenditure of limited resources on unproven behavioral therapies for individuals with autism. Considerations that need to be reviewed before adopting a behavioral treatment are outlined, including the need to establish whether direct effects can be attributed to a treatment. (Contains 11…

This commentary discusses study results that indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in treating repetitive or ritualized behaviors in children with autism. The need for concurrent genetic and biochemical…

This article reviews the psychopharmacological treatment of aggression, mood disturbances, and self-injurious behavior in persons with autistic disorder. It highlights the use of dopaminergic drugs, serotonergic drugs, opioidergic drugs, adrenergic drugs, thymoleptic drugs, and glutamatergic drugs for their potential utility in treating…

This commentary uses self-injurious behavior to illustrate the approach of the functional analysis of behavior as a guide to rational treatment strategies for individuals with autism, and to show that the characteristics of the clinical presentations can provide clues for underlying mechanisms that can be used for research and treatment. (Contains…

This commentary discusses the use of pharmacological treatments to reduce over activity and hyperactivity in children with autism. While it concedes that some medications, particularly antipsychotics, can effectively reduce over activity, it cautions that the effects of psychotropic medications on inattention remain poorly defined and stresses the…