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50 Years of ERIC
50 Years of ERIC
The Education Resources Information Center (ERIC) is celebrating its 50th Birthday! First opened on May 15th, 1964 ERIC continues the long tradition of ongoing innovation and enhancement.

Learn more about the history of ERIC here. PDF icon

Showing 1 to 15 of 18 results
Brief Report: Bone Fractures in Children and Adults with Autism Spectrum Disorders
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Neumeyer, Ann M.; O'Rourke, Julia A.; Massa, Alexandra; Lee, Hang; Lawson, Elizabeth A.; McDougle, Christopher J.; Misra, Madhusmita – Journal of Autism and Developmental Disorders, 2015
Peripubertal boys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. However, it is not clear whether lower BMD in ASD results in an increased fracture rate. This study examined the rate of fractures in children and adults with and without ASD using a national database of emergency room…
Descriptors: Autism, Pervasive Developmental Disorders, Physiology, Children
Brief Report: Pilot Single-Blind Placebo Lead-in Study of Acamprosate in Youth with Autistic Disorder
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Erickson, Craig A.; Wink, Logan K.; Early, Maureen C.; Stiegelmeyer, Elizabeth; Mathieu-Frasier, Lauren; Patrick, Vanessa; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2014
Rationale: An excitatory/inhibitory (E:I) imbalance marked by enhanced glutamate and deficient gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of autism spectrum disorders (ASD). Objectives: We report on the first single-blind placebo lead-in trial of acamprosate, a drug with putative mechanisms restoring E:I…
Descriptors: Autism, Pervasive Developmental Disorders, Drug Therapy, Metabolism
Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders
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Hallett, Victoria; Lecavalier, Luc; Sukhodolsky, Denis G.; Cipriano, Noreen; Aman, Michael G.; McCracken, James T.; McDougle, Christopher J.; Tierney, Elaine; King, Bryan H.; Hollander, Eric; Sikich, Linmarie; Bregman, Joel; Anagnostou, Evdokia; Donnelly, Craig; Katsovich, Lily; Dukes, Kimberly; Vitiello, Benedetto; Gadow, Kenneth; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2013
This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry…
Descriptors: Anxiety, Symptoms (Individual Disorders), Children, Pervasive Developmental Disorders
Brief Report: Social Disability in Autism Spectrum Disorder--Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials
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Scahill, Lawrence; Hallett, Victoria; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Tierney, Elaine; Deng, Yanhong; Dziura, James; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2013
There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to…
Descriptors: Autism, Pharmacology, Effect Size, Pervasive Developmental Disorders
Predictors and Moderators of Parent Training Efficacy in a Sample of Children with Autism Spectrum Disorders and Serious Behavioral Problems
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Farmer, Cristan; Lecavalier, Luc; Yu, Sunkyung; Arnold, L. Eugene; McDougle, Christopher J.; Scahill, Lawrence; Handen, Benjamin; Johnson, Cynthia R.; Stigler, Kimberly A.; Bearss, Karen; Swiezy, Naomi B.; Aman, Michael G. – Journal of Autism and Developmental Disorders, 2012
The Research Units on Pediatric Psychopharmacology-Autism Network reported additional benefit when adding parent training (PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat analyses were rerun with putative predictors and moderators. The "Home Situations Questionnaire"…
Descriptors: Behavior Problems, Autism, Hyperactivity, Predictor Variables
Case Report: 16-Year-Old Male with Autistic Disorder with Preoccupation with Female Feet
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Early, Maureen C.; Erickson, Craig A.; Wink, Logan K.; McDougle, Christopher J.; Scott, Eric L. – Journal of Autism and Developmental Disorders, 2012
This paper highlights clinical challenges faced when diagnosing and then treating an individual presenting to a child and adolescent psychiatry clinic because of unwelcome comments he made to female peers about their feet. Novel use of exposure therapy helped him effectively decrease his comments from 1 to 2 times per month to once every 6 months.…
Descriptors: Sexual Harassment, Psychiatry, Males, Adolescents
Brief Report: Acamprosate in Fragile X Syndrome
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Erickson, Craig A.; Mullett, Jennifer E.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2010
Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). We report on the first trial of acamprosate, a drug with putative mGluR5 antagonism, in three adults with FXS and autism. Medical records describing open-label treatment with acamprosate in 3 patients with FXS and a comorbid diagnosis of autistic disorder…
Descriptors: Autism, Mental Retardation, Drug Therapy, Genetic Disorders
Open-Label Memantine in Fragile X Syndrome
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Erickson, Craig A.; Mullett, Jennifer E.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2009
Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). The purpose of this pilot study was to examine the effectiveness and tolerability of memantine for a number of target symptoms associated with FXS. Medical records describing open-label treatment with memantine in 6 patients with FXS and a comorbid…
Descriptors: Mental Retardation, Rating Scales, Patients, Genetic Disorders
A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder
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Handen, Benjamin L.; Melmed, Raun D.; Hansen, Robin L.; Aman, Michael G.; Burnham, David L.; Bruss, Jon B.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2009
Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2-17 years) with autism and persistent GI…
Descriptors: Autism, Children, Human Body, Drug Therapy
Trial Design Challenges when Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
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Scahill, Lawrence; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Handen, Benjamin; Johnson, Cynthia; Dziura, James; Butter, Eric; Sukhodolsky, Denis; Swiezy, Naomi; Mulick, James; Stigler, Kimberly; Bearss, Karen; Ritz, Louise; Wagner, Ann; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2009
This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes…
Descriptors: Intervention, Pervasive Developmental Disorders, Parent Education, Drug Therapy
Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders
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Nikolov, Roumen N.; Bearss, Karen E.; Lettinga, Jelle; Erickson, Craig; Rodowski, Maria; Aman, Michael G.; McCracken, James T.; McDougle, Christopher J.; Tierney, Elaine; Vitiello, Benedetto; Arnold, L. Eugene; Shah, Bhavik; Posey, David J.; Ritz, Louise; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2009
Objective: To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods: One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to…
Descriptors: Pervasive Developmental Disorders, Children, Symptoms (Individual Disorders), Comparative Analysis
Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity
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Jahromi, Laudan B.; Kasari, Connie L.; McCracken, James T.; Lee, Lisa S-Y.; Aman, Michael G.; McDougle, Christopher J.; Scahill, Lawrence; Tierney, Elaine; Arnold, L. Eugene; Vitiello, Benedetto; Ritz, Louise; Witwer, Andrea; Kustan, Erin; Ghuman, Jaswinder; Posey, David J. – Journal of Autism and Developmental Disorders, 2009
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of…
Descriptors: Pervasive Developmental Disorders, Hyperactivity, Self Control, Interpersonal Communication
Gastrointestinal Factors in Autistic Disorder: A Critical Review
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Erickson, Craig A.; Stigler, Kimberly A.; Corkins, Mark R.; Posey, David J.; Fitzgerald, Joseph F.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2005
Interest in the gastrointestinal (GI) factors of autistic disorder (autism) has developed from descriptions of symptoms such as constipation and diarrhea in autistic children and advanced towards more detailed studies of GI histopathology and treatment modalities. This review attempts to critically and comprehensively analyze the literature as it…
Descriptors: Autism, Symptoms (Individual Disorders), Children, Pathology
Brief Report: Autistic Disorder in Three Children with Cytomegalovirus Infection
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Sweeten, Thayne L.; Posey, David J.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2004
Previous research has identified a relationship between autistic disorder (autism) and specific congenital infections. Three cases of congenital or perinatal cytomegalovirus (CMV) infection occurring in association with autism are described. Hypothetical mechanisms relating congenital infection, such as CMV, to the development of autism are…
Descriptors: Etiology, Autism, Children, Microbiology
Repetitive Thoughts and Behavior in Pervasive Developmental Disorders: Treatment with Serotonin Reuptake Inhibitors.
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McDougle, Christopher J.; Kresch, Laura E.; Posey, David J. – Journal of Autism and Developmental Disorders, 2000
Results from two studies indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in children with autism. A study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive…
Descriptors: Adults, Behavior Disorders, Behavior Problems, Children
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