This paper reviews the literature examining social skills training (SST) programs for youth with AS/HFA, with an emphasis on critically evaluating efficacy and highlighting areas of future research. The review highlights the disparity between SST programs described in the extant literature, including lack of a universal definition of social…

Although research in autism has grown more sophisticated, the gap between research knowledge and applicability of research in real world settings has grown. There have been a number of different reviews of evidence-based practices of treatments for young children with autism. Reviews which have critically evaluated the empirical evidence have not…

Patterns of sensory abnormalities in children and adults with autism were examined using the Diagnostic Interview for Social and Communication Disorders (DISCO). This interview elicits detailed information about responsiveness to a wide range of sensory stimuli. Study 1 showed that over 90% of children with autism had sensory abnormalities and had…

The concurrent validity of the original and revised versions of the Leiter International Performance Scale was examined with 26 children (ages 4-16) with autism. Although the correlation between the two tests was high (.87), there were significant intra-individual discrepancies present in 10 cases, two of which were both large and clinically…

This study assessed the criterion-related validity of the PDD Behavior Inventory, a rating scale to evaluate the adaptive and maladaptive behaviors of children with pervasive developmental disorders. Good correlations with five other scales confirmed the scale's validity and suggest its value in assessing treatment-related changes in maladaptive…

This study compared 29 females with Turner syndrome and 21 females with fragile X syndrome (ages 6-22) on a videotaped role-play interaction with 34 females in a comparison group. Three of eight behavioral measures of social skills differentiated the participant groups. Fragile-X subjects required more time to initiate interactions and Turner…

This study assessed depression, anxiety, and relevant cognitions in 46 adults with borderline, mild, or moderate mental retardation. Consistent with research on other groups, self-reports of depression and anxiety were highly correlated and cognitions were strong predictors of negative affect. Hierarchical multiple regression analyses offered…

This prospective open-label study assessed the efficacy and tolerability of low-doze fluvoxamine in 14 children with pervasive developmental disorders (PDDs). Although there was no response for the group as a whole, eight subjects were considered at least partial responders in intent-to-treat analyses. Results suggest fluvoxamine can be beneficial…

This study examined Autism Diagnostic Interviews Revised (ADI-R) data for 69 autistic subjects from multiplex (MP) families (with more than one autistic member) and 88 autistic subjects from singleton (SP) families (with only one autistic member). Multivariate analysis revealed no differences between verbal or nonverbal MP and SP groups for ADI-R…

Plasma amino acid levels were measured in autistic (n=12), Asperger syndrome (n=11) patients, their parents and siblings. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenyalanine, asparagine, tyrosine, alanine, and lysine levels than age-matched controls. Results suggest dysregulated amino…

This study examined behavioral adjustment in 22 siblings of children with autism. Mothers rated these children as having more behavior problems and fewer prosocial behaviors than a normative sample. Analysis of variables revealed that male siblings and children younger than the autistic sibling engaged in fewer prosocial behaviors. Psychological…

This paper reports a clinical case of autism with a deletion on chromosome 2 in a young male with high functioning autism. The deletion seems to correspond with regions emerging from linkage studies. The paper proposes this chromosomal region as a possible candidate region in the search for autism genes. (Contains references.) (Author/DB)

This study of hyperlexia in 80 children with developmental delays found no significant differences in the frequency of hyperlexia in girls compared with boys; a significantly elevated frequency of hyperlexia in children diagnosed with pervasive developmental disorders (PDD) compared with children with non-PDD diagnoses; and a similar range of IQ…

To examine how mothers cope with the stresses of raising a child with autism, mothers of children with (n=29) and without (n=29) autism were interviewed. Results supporting seven hypotheses suggest that mothers may redefine their roles as a coping strategy. Life satisfaction for mothers of children with autism was positively associated with…

This study explored the ability of 14 individuals with autism to generate a unique series of digits. Individuals with autism were more likely to repeat previous digits than comparison individuals, suggesting they may exhibit a shortfall in response inhibition. Results support the executive dysfunction theory of autism. (Contains references.)…