Children who are significantly inattentive and poor early readers require intervention, and traditional tutoring approaches may not be effective with this group. Using a single-subject, multiple-baseline-across-participants design, Study 1 examines whether a computer-assisted reading intervention increases performance for three first-grade children with teacher-rated inattention and early reading problems. Study 2 replicates this intervention using three second-grade students. The independent variable was an evidence-based computer-assisted intervention (Earobics). Dependent variables were oral reading fluency, phoneme segmentation, and attention-to-task. Results provide evidence of reading gains, suggesting moderate size effects. For all, attention-to-task was higher during the computer-assisted intervention than during small-group reading instruction. Implications for practice and future research are discussed. The use of computer-assisted interventions for children who are inattentive and poor early readers may be an effective solution to improve reading performance.