In view of student shift away from science at advanced levels, and gender and locale based divergence in interest in studying physics, chemistry and biology, this study explores experience categories that significantly contribute to interest in science on a sample of upper primary school students from Kerala, India. A series of multiple regression analyses, on data from a Likert type scale of Out-of-school Science Experiences and Scale of Interest in Science towards frequency of experience and degree of interest respectively, revealed moderate influence of out-of-school experiences on interest in science. While biology related experiences and chemistry experiments influence interest in science more among girls, physics activity and biology experimentation influenced boys' interest more. Simple experimental acts are more influential on interest in science for girls than boys. Urban students' enhanced interest in science over their rural counterparts is attributable to the former's more indirect, vicarious experiences, including observation. (Contains 3 tables.)