Objective: To examine if students who re-visit the school nurse use medicines differently than other students when exposed to aches and psychological problems. Methods: The study includes all 11-, 13- and 15-year-old students from a random sample of schools in Denmark, response rate 87 per cent, n = 5,205. The data collection followed the internationally standardized HBSC questionnaire. This study includes an item about students' re-visits to the school nurse, items about frequency of four complaints (headache, stomach-ache, difficulties in getting to sleep, and nervousness) and medicine use in the past month for these four complaints. Results: In total, 8.6 per cent of the students had re-visited the school nurse. There was a strong and graded association between frequency of complaints and medicine use for the relevant complaint. Students who re-visited the school nurse had higher odds for medicine use than other students. The association between frequency of complaints and medicine use was stronger among students who had not re-visited the school nurse as compared to the students who had re-visited the school nurse. One example is the OR (95 per cent CI) for medicine use for headache among students who experienced headache monthly vs. seldom/never and at least weekly vs. seldom/never. Among students who did not re-visit the school nurse, the OR estimates were 5.32 (4.61-6.14) and 13.6 (10.5-17.6) and among students who did, OR estimates were 3.65 (2.32-5.75) and 7.07 (3.58-14.0). Conclusion: The school nurse may reduce the students' proneness to use medicine when they experience complaints. (Contains 3 tables and 1 figure.)