A significant body of education literature has begun using multilevel statistical models to examine data that reside at multiple levels of analysis. In order to provide a primer for medical education researchers, the current work gives a brief overview of some issues associated with multilevel statistical modeling. To provide an example of this technique, we then present a multilevel analysis examining the relationship between two individual-level variables and the "cross-level" interaction between this relationship and a school-level variable. In offering this discussion and example of multilevel modeling, we hope to provide medical educators with a basic introduction to multilevel statistics, including the advantages of utilizing these techniques.