Objective: The objective of the RESPECT approach to tailored telephone education (TTE) is described. This approach was shown to be highly effective through a randomized intervention trial for increasing the rate of colorectal cancer (CRC) screening. Methods: At the conclusion of the trial, the investigators identified the main principles that exemplified the TTE. This was accomplished through a review of chart notes and discussion. Results: The concept underlying our TTE approach was RESPECT for the audience, and was based on: (1) Rapport; (2) Educate, but don't overwhelm; (3) Start with people where they are; (4) Philosophical orientation based on a humanistic approach to education; (5) Engagement; (6) Care and show empathy; and (7) Trust. Conclusions: An advantage of using principles of practice is that it may be more feasible to apply general principles than specific activities because they can be adapted to different social contexts and audiences.