This issue of "Early Developments" examines a relatively new phenomenon in the early childhood field called "evidence-based practice," defined herein as "a decision-making process that integrates the best available research evidence with family and professional wisdom and values." This issue of "Early Developments" includes the following articles: (1) Evidenced-Based Practice: Recognizing Different Ways of Knowing; (2) Recognition & Response: Establishing the Evidence for an Early Intervening System; (3) Infusing Evidence-Based Practice into Professional Development: Creating a Cross-Agency Professional Development System; (4) Creating a New Vision of Early Education: FPG's FirstSchool Initiative; and (5) Odom Appointed FPG Director: An Interview with Sam Odom. Also included in this issue are: Recent Grants; Research Highlights; and Published Research. ["Early Developments" is published by the FPG Child Development Institute at The University of North Carolina at Chapel Hill.]