Teaching practices in natural settings such as activity-based intervention (ABI) are suggested as alternatives to be used in effective early childhood education. As a multidisciplinary model, ABI consists of four components, which are choosing activities according to the child's interests; teaching generalizable goals embedded in routines and planned activities; and using before and after behavior stimuli which have natural and meaningful relations with behaviors. The benefits of using ABI within instructional settings include providing children with multiple-practice opportunities; teaching the target skill within the framework of daily routines without further need for any extra activity; focusing on children's interests and intrinsic motivation; and enhancing the level of success in educational settings. Considering these advantages and benefits, one can state that practices based on activity-based intervention can be used effectively for children with developmental disabilities from various age and disability groups. This article included descriptions and examples of activity-based intervention.