This research develops and empirically tests a factor model for understanding college students' acceptance of Tablet PC (TPC) as a means to forecast, explain, and improve their usage pattern in education. The analysis involved more than 230 students from a regional Midwestern institution. Overall, our model exhibited a good fit with the data and provided satisfactory explanatory power for students' acceptance of TPC in an educational setting. Analysis of the results suggests a number of implications to educational institutions. Most notably are the need for programs aimed at influencing students' attitudes and perceptions towards TPC, creating an environment of a positive image surrounding the use of TPC on campus, and facilitating the use of TPC. (Contains 5 tables and 2 figures.)