The contributions to this issue share a focus on design of e-learning environments. Instructional designers stand at very early stages of knowledge in this area, but with great potential for growth and progress. This commentary offers an activity-based perspective on e-learning environments, resulting in a flexible stance toward instructional strategies, artifact design, emergent activity, and learning outcomes. This same flexibility should be evident as we in the field appropriate theories from other disciplines and develop some of our own. I support the contributors' call for more design research specifically addressing challenging problems of practice encountered by design practitioners.