This research aimed to develop a model of e-learning by using Problem-Based Learning--PBL to develop thinking skills for students in Rajabhat University. The research is divided into three phases through the e-learning model via PBL with Constructivism approach as follows: Phase 1 was to study characteristics and factors through the model to develop thinking skills, Phase 2 was to construct the model to develop thinking skills, Phase 3 was to study the effects of implementing from the model to develop thinking skills. The findings found that: There are five factors in the model of e-learning--principle, purpose, learning and teaching process, systematic procedures, and measurement and evaluation. There are nine stages of learning and teaching activities: faced problem, defined problem, defined boundary to collect facts, setting hypothesis, allocated problem topic to group members, group members' collected data, analyzed and synthesized data, decision making, and evaluation. By the learning set through the model of e-learning with problem-based learning in constructivism approach to develop their thinking skills, students at Rajabhat University, as the subject study, significantly achieved their post-test scores more highly than their pre-test at 0.05. Otherwise, the students' opinions on the model used indicated in high degrees. The students in this study significantly showed the development of their thinking skills in higher degree at 0.05.