Knowledge is an important concept for individuals and organizations both as a power and source. Thus, knowledge management has become important subject for researchers. However, when people encounter problems, they usually try to produce solutions by utilizing their previous knowledge and experience. Such problem solving strategies are called "Knowledge Inertia". Purpose of this study is to test the level of relationship interaction between knowledge inertia, organizational learning and organizational performance. In line with this purpose, six hypotheses were developed. Sample of the research consists of 405 teachers who work in Diyarbakir City Central Districts (Baglar, Kayapinar, Sur and Yenisehir). In this research, relational survey model was utilized. Also Knowledge Inertia Scale, Organizational Learning Scale and Organizational Performance Scale were utilized. For confirmatory factor analyses and structural equality model, SPSS and AMOS packaged software were utilized. Goodness of fit indexes of the developed model are RMSEA = 0.060; SRMR = 0.069; CMIN\DF = 2,475; GFI = 0.922; CFI = 0.964; AGFI = 0.911; NFI = 0.905; Chi squared = 2395,329; df = 968 and p = 0.000. This result shows that the fit values of the model are acceptable and at desired level. First of the most important findings of the study is that knowledge inertia and organizational learning are significant predictors of organizational performance. Second is that organizational learning has a function of mediator between knowledge inertia and organizational performance.