During student-centered learning, the individual assumes responsibility for determining learning goals, monitoring progress toward meeting goals, adjusting or adapting approaches as warranted, and determining when individual goals have been adequately addressed. This can be particularly challenging while learning from the World-Wide Web, where billions of resources address a variety of needs. The individual must identify which tools and resources are available and appropriate, how to assemble them, and how to manage and support their unique learning goals. We analyze the applicability of cognitive principles to learning from Web-based multimedia, review and critically analyze issues related to cognition and student-centered learning from Web-based multimedia, and describe implications for design research and practice.