This cross-sectional study examined relationships between job-specific stressors and psychological and physical health symptoms in academic employees working in UK universities. The study also tests the main and moderating role played by sense of coherence (SOC: Antonovsky, 1987 in work stress process). SOC is described as a generalised resistance resource for coping with environmental stressors and remaining healthy. Four hundred and sixty-five academic employees (60% male) completed measures of work stressors, physical and psychological ill health and SOC. Significant inter-relationships were found between job stressors, health outcomes and SOC. Stressors relating to time constraints, support and influence and work-home interface demands had the strongest associations with health outcomes. Employees with a weaker SOC tended to be in poorer physical and psychological health, thus supporting a main effect for SOC. Some evidence for a moderating role for SOC was found, with the strongest effect observed for stressors experienced at the work-home interface. (Contains 3 tables and 1 figure.)