This article describes and discusses, some of the 100 structural differences between the male and female brain identified by some researchers. Teachers need to be aware of these differences, and how they manifest themselves in male and female students. If teachers are not familiar with these differences, and how they affect learning styles, learning disabilities, and conduct disorders could be misdiagnosed. These differences are both genetic and socialized and include some of the following: (1) Verbal/spatial differences; (2) P cells and M cells; (3) Frontal lobe development; (4) Neural rest states; (5) Cross talk between hemispheres; and (6) Natural aggression.