The purpose of this study was to systematically replicate and extend previous studies of the TOUCHMATH program, a multi-sensory mathematics program (Bullock, Pierce, & McClellan, 1989). Three middle school students with moderate and multiple disabilities (e.g., autism and moderate intellectual disabilities) participated. Students were taught how to solve single-digit mathematics problems using TOUCHMATH and a number line. An alternating-treatments design across participants (Barlow & Hersen, 1984) was utilized to evaluate and compare the effects of both strategies. Results indicated that the TOUCHMATH strategy was more effective and efficient in teaching students' single-digit addition problems compared to the use of the number line. Limitations of the study, implications for practice for classroom teachers, and suggestions for future research are discussed. (Contains 1 figure.)