This article describes an approach to general chemistry that involves teaching chemical concepts in the context of two thematic laboratory modules: environmental remediation and the fate of pharmaceuticals in the environment. These modules were designed based on active-learning pedagogies and involve multiple-week projects that dictate what content is taught and in which order the content is presented. Students were expected to design experimental procedures, analyze data, and communicate their results. A description of the two laboratory modules is included along with a week-by-week description of the student experience.