This study compared and illustrated four differential distractor functioning (DDF) detection methods for analyzing multiple-choice items. The log-linear approach, two item response theory-model-based approaches with likelihood ratio tests, and the odds ratio approach were compared to examine the congruence among the four DDF detection methods. Data from a college-level mathematics placement test were analyzed to understand the causes of differential functioning. Results indicated some agreement among the four detection methods. To facilitate practical interpretation of the DDF results, several possible effect size measures were also obtained and compared.