As Yogi Berra said, "Predictions are hard, especially about the future." In this article, the author offers a few forward-looking observations about the emerging impact of information technology on scientific research. Scientific research refers to a particular method for acquiring knowledge about natural phenomena. This method has two dimensions: one of "observation and experimentation" and one of "description and explanation." The author explores these two questions: (1) Are some of the current uses of information technology in scientific research redefining traditional scientific research?; and (2) Has the computer revolution produced a "new renaissance," one that has resulted in the creation of additional, new paradigms of science? (Contains 8 notes.)