This article discusses five interaction strategies that can be used in large-scale (more than thirty participants) Web-based training. Evaluation data are presented from seven Web-based continuing education workshops conducted with United States Department of Education Middle School Drug Prevention and School Safety Coordinators (MSCs) that used two of these large-scale strategies. Results show, contrary to the current literature, MSCs who participated in large-scale Web-based training were highly satisfied with many aspects of the workshops, including the online facilitation. The results point to a need to replicate these findings and to further study additional large-scale interaction strategies in Web-based training and professional development.