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Direct linkLightbody, Amy A.; Reiss, Allan L. – Developmental Disabilities Research Reviews, 2009
Fragile X syndrome (FraX) remains the most common inherited cause of intellectual disability and provides a valuable model for studying gene-brain-behavior relationships. Over the past 15 years, structural and functional magnetic resonance imaging studies have emerged with the goal of better understanding the neural pathways contributing to the…
Descriptors: Genetic Disorders, Mental Retardation, Genetics, Brain
Gothelf, Doron; Furfaro, Joyce A.; Penniman, Lauren C.; Glover, Gary H.; Reiss, Allan L. – Mental Retardation and Developmental Disabilities Research Reviews, 2005
Studying the biological mechanisms underlying mental retardation and developmental disabilities (MR/DD) is a very complex task. This is due to the wide heterogeneity of etiologies and pathways that lead to MR/DD. Breakthroughs in genetics and molecular biology and the development of sophisticated brain imaging techniques during the last decades…
Descriptors: Intelligence Quotient, Genetic Disorders, Mental Retardation, Developmental Disabilities
Hessl, David; Rivera, Susan M.; Reiss, Allan L. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Fragile X syndrome (FXS), caused by a single gene mutation on the X chromosome, offers a unique opportunity for investigation of gene-brain-behavior relationships. Recent advances in molecular genetics, human brain imaging, and behavioral studies have started to unravel the complex pathways leading to the cognitive, psychiatric, and physical…
Descriptors: Learning Problems, Genetics, Memory, Brain
