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Schneider, Andrea; Ligsay, Andrew; Hagerman, Randi J. – Developmental Disabilities Research Reviews, 2013
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical…
Descriptors: Genetic Disorders, Aging (Individuals), Research, Developmental Disabilities
Hagerman, Paul J.; Hagerman, Randi J. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Carriers of fragile X mental retardation 1 ("FMR1") premutation alleles (55 to 200 CGG repeats) are generally spared the more serious neurodevelopmental problems associated with the full-mutation carriers (greater than 200 repeats) of fragile X syndrome. However, some adult male premutation carriers (55-200 repeats) develop a neurological syndrome…
Descriptors: Incidence, Genetic Disorders, Genetics, Neurological Impairments
Loesch, Danuta Z.; Huggins, Richard M.; Hagerman, Randi J. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Data on the relationships between cognitive and physical phenotypes, and a deficit of fragile X mental retardation 1 (FMR1) gene-specific protein product, FMRP, are presented and discussed in context with earlier findings. The previously unpublished results obtained, using standard procedures of regression and correlations, showed highly…
Descriptors: Mental Retardation, Intelligence Quotient, Short Term Memory, Foreign Countries

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