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Direct linkSundaram, Senthil K.; Chugani, Harry T.; Chugani, Diane C. – Mental Retardation and Developmental Disabilities Research Reviews, 2005
Positron emission tomography (PET) is a technique that enables imaging of the distribution of radiolabeled tracers designed to track biochemical and molecular processes in the body after intravenous injection or inhalation. New strategies for the use of radiolabeled tracers hold potential for imaging gene expression in the brain during development…
Descriptors: Genetic Disorders, Mental Retardation, Developmental Disabilities, Genetics
Chugani, Diane C. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development--and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This…
Descriptors: Epilepsy, Autism, Brain, Metabolism
