This article describes how a traditional biology lecture course was transformed into an interactive class. A review the activities used, changes made to grading policy, and practical tips for integration of active learning in the classroom are provided. Analysis of student responses to course assessments indicated that active learning experiences helped them focus on and understand key concepts of the course. Students performed as well as, or better than, those in previous classes that used a more traditional lecture technique. Active learning enriches the classroom learning experience and can be incorporated into a large lecture setting with relative ease.