The purpose of this study was to examine the association between student-life stress and health related quality of life (HRQOL) among Doctor of Pharmacy (Pharm.D.) students. Data were collected for 166 students in the first three years of a Pharm.D. curriculum. Student-Life Stress Inventory scores were significantly negatively correlated to mental component SF-12 HRQOL scores (p is less than 0.004) for the overall sample (r = -0.58), gender (rfemale = -0.56, rmale = -0.56) and within each professional year (rfirst-year = -0.50, rsecond-year = -0.49, rthird-year = -0.68). However, z-tests indicated that the magnitude of the correlations did not vary significantly by gender or year in the curriculum. Strategies are needed to reduce Student-Life Stress and improve the mental component of HRQOL.