Recent work in the bilingual literature suggests that naming pictures in a second language (L2) differs from naming pictures in the first language (L1) because of effortful lexical retrieval. his finding has received some support in the neuroimaging literature (De Blesser et al., 2003). In the current study, twelve Spanish-English bilinguals, who had learned English later in early adulthood, were asked to name pictures covertly in either Spanish or English while being scanned with functional Magnetic Resonance Imaging (fMRI). Picture naming in the second language (L2) relative to the native language (L1) revealed increased activity in the right insula, anterior cingulate gyrus and dorsolateral prefrontal cortex (DLPFC) and the left fusiform gyrus. These results are consistent with the view that picture naming in a less proficient L2 requires increased effort to establish links between motor codes and visual forms. [Support for this research was provided by the Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, Pierson-Lovelace Foundation, Tamkin Foundation, Jennifer Jones-Simon Foundation, The Capital Group Companies Charitable Foundation, Robson Family, and the Northstar Fund.]