This article reports an open-access journal from the Public Library of Science that has begun an online publication, offering all readers the opportunity to post comments. The site is in trial status, but registered readers will soon be able to rate each article on merit. The idea is that the best papers will bubble to the top; the wisdom of the masses (or, at least, of interested readers of science) rather than a set of editors will determine which are the most important contributions. For now, anyone who registers on the site may comment on any of the posted papers or even flag specific passages. Such notes, indicated by blue "conversation" balloons within the text, include links to potentially useful databases and challenges to particular assumptions made by the authors.