Across the United States, civic leaders from all sectors are working avidly to identify education and workforce strategies that can bolster regional economic development. One notable success story is found in Louisville, Kentucky, where a broad coalition of local leaders identified powerful educational improvement strategies and then successfully mobilized the community around those strategies. That work, spotlighted in a landmark meeting of leaders that the Business-Higher Education Forum (BHEF) sponsored in Louisville October 28-29, 2010, is the focus of this publication. The meeting, "Cities for Success: A BHEF Leadership Summit", was supported by BHEF's members and through the generosity of the American Fidelity Foundation. The summit was part of an ongoing BHEF effort, the College Readiness, Access, and Success Initiative (CRI), through which prominent leaders in business and higher education work together to promote college readiness, access, and degree completion--particularly in math and science--for underserved populations, and seek to address the misalignment between workforce needs and student preparation and interest.