Background: "Hooking up" behaviors, or sexual activities without commitment or emotional attachment, are occurring among college students. Purpose: This study examined the relationship between hooking up and two measures of religiosity. Methods: Data was obtained from students at a mid-southern university (n=459). Results: Most respondents indicated that they have hooked up. Males (64%) were more likely to report the behavior than females (47%). Religious attendance and religious belief played a significant role in distinguishing between those who have and have not participated in hooking up behaviors. Discussion: Results indicate religiosity may determine involvement in casual high-risk sexual encounters that expose college students to sexually transmitted infections and unintended pregnancy. Translation to Health Education Practice: Results should be of value to college-level sexuality educators and considered by those involved in sexual health programming on college campuses. (Contains 3 tables.)