This article highlights the problem of substance use and abuse among adolescents and discusses the important role of school leaders in addressing this problem. Drug and alcohol use among adolescents is a significant and serious problem. In fact, an alarmingly high number of students report that they have used drugs or alcohol. Substance use and abuse is societal problem that schools alone cannot fix, but they can play an important role in education, prevention, and intervention. School leaders can help students, parents, and staff members be aware of the risks associated with substance use and abuse, the ways of preventing students from using and abusing substances, and the treatment resources that are available for students who may need help. Principals also can collaborate with community service providers to ensure that school policies and programs are supported by community services. Their commitment to addressing substance use and abuse is integral to creating safe and productive learning environments for all students. Principals will be most effective if they take a proactive approach to drinking and substance use, empower faculty and staff members to implement evidence-based programs, and provide the resources necessary to support such programs.