The present study examined cultural orientation as a protective factor against tobacco and marijuana smoking for African American young women (ages 18 to 25). African American college students (N = 145) from a predominantly White university were administered subscales from the African American Acculturation Scale-Revised (AAAS-R); the shortened Individualism/Collectivism (INDCOL) Scale; a Tobacco and Drug Use Survey; and a background survey. Multiple logistic regression was conducted using cultural orientation variables as predictors and smoking status (i.e., tobacco and marijuana) as the criterion. It was expected that young women who endorsed traditional African American cultural characteristics (i.e., religious beliefs, health, family values, and socialization) and were collectivistic in their community (i.e., cultural interdependency) and familial (i.e., familial interdependency) interactions would be less likely to smoke. Results show that traditional religious beliefs and practice was protective against tobacco smoking for this sample of young women. Familial interdependency (e.g., supportive exchanges between friends, and consultation and sharing with parents), and traditional religious beliefs and practices surfaced as protective factors against marijuana smoking. Traditional health beliefs and practices was a risk factor for both tobacco and marijuana smoking. The implications signal the need for smoking prevention and cessation programs to focus on interpersonal factors which may strengthen African American young women's religious and familial bonding.