A school can change. In this case study, the authors describe the 12 factors they have identified as being key in the transformation of the core pedagogical practices at Nan Chiau Primary School, Singapore, from direct instruction to inquiry, from a 20th to a 21st century school. While the adoption of 1:1 mobile devices played a catalytic role in the school's transformation, in order for the school-level transformation to be scaled and sustained, all the factors needed to be addressed. As the 12 factors are culturally neutral, the experiences in Singapore have relevance to the ongoing school change conversation in the U.S. and in other countries.