With the rise in advanced-degree seeking women and the minimal research on the dual impact of sexism and role overload, the current study aims to better understand the impact of sexism and role overload on psychological distress in a particular sample of advanced-degree seeking women. Seventy-six female medical student participants (mean age 24.7) from a southeastern health sciences university were recruited to participate in this study. Perceived sexist events were significantly correlated with depressive symptoms, with the exception of lifetime sexist events, anxious symptoms, and stress. Consistent with predictions, perceived sexist events were also positively correlated with role overload. In addition, role overload was positively correlated with psychological distress. Role overload was found to mediate the relationships between perceived sexist events and psychological distress in this sample, suggesting that it may impact psychological distress more than sexist events. Directions for future research and implications for women who experience sexism and role overload and who suffer from psychological distress are discussed.