The Sex Squad is a collective of US-based college students, who create and perform monologues, scenes and musical parodies for ninth graders (ranging in age from 13 to 15). The Sex Squad is the central element in the "AMP!" programme for adolescent sexual health, developed at the University of California-Los Angeles in collaboration with the HIV/AIDS Prevention Unit of the Los Angeles Unified School District. In this case study, grounded primarily in arts-based approaches to sexual health, we, the founders, draw on our own experiences with, and critical reflections on, Sex Squad to make a case for including humour in sexual health education. In particular, we are committed to investigating how the arts can radicalise sexual health education, to increase its effectiveness, but also to reinforce sex as a valuable and pleasurable aspect of the human experience.