Kristin Roovers was a postdoctoral fellow at the University of Pennsylvania with a bright career ahead of her--a trusted member of a research laboratory at the medical school studying the role of cell growth in diabetes. When an editor of "The Journal of Clinical Investigation" did a spot-check on one of her images for an article in 2005, Roovers' images were found to have been fabricated in order to support conclusions. As computer programs make images easier than ever to manipulate, editors at a growing number of scientific publications are turning into image detectives, examining figures to test their authenticity. The level of tampering they find is alarming. This article describes how new tools are helping journal editors detect manipulated images.