This article provides quantitative data to establish the relative, perceived burden of writing research articles in English as a second language. Previous qualitative research has shown that scientists writing English in a second language face difficulties but has not established parameters for the degree of this difficulty. A total of 141 Mexican, Spanish-speaking scientists from a range of scientific disciplines participated in a survey which directly compared writing scientific research articles in Spanish and English as a second language. The survey questions defined burden in relation to perceived difficulty, dissatisfaction, and anxiety. The results revealed that the experience of writing a scientific research article in English as a second language is significantly different than the experience writing in a first language and that this writing process was perceived as 24% more difficult and generated 11% more dissatisfaction and 21% more anxiety. The findings suggest that the use of English as a second language is the cause of this increased burden. (Contains 1 table.)