Anxiety disorders are the most common mental health concerns in the United States and they tend to be among the most frequently reported in college mental health. While efficacious research for the psychotherapy treatment of specific anxiety disorders (e.g., social phobia, panic disorder, etc.) exists, the picture is more complex in clinical practice especially with students who are treated as a whole person, usually involving multiple co-existing disorders as well as normal developmental challenges of adjusting to college. This chapter reviews the evidenced-based research for anxiety disorders in both the general population and the college student population, as well as evidence for therapist/relationship factors. It examines the numerous challenges for conducting effectiveness studies in college mental health, suggestions for working with chronically anxious college students, and future directions for research and practice in this area. (Contains 2 tables.)