The purpose of this safety manual is to provide a resource to help manage and minimize potential risks in science classrooms where students spend up to 60% of instructional time engaged in hands-on activities. This manual contains information on standards, legal aspects, and responsibilities for science safety; general laboratory safety for students; laboratory facility design; lab safety equipment and accident response; first aid; laboratory equipment safety; chemicals; plants and fungi; animals; and animal safety considerations for biological laboratories. The laboratory safety and accident response section addresses issues such as eye protection, eyewash stations, safety showers, earthquake preparedness, and general housekeeping. (DDR)