Objective: To identify and quantify factors that contribute to rural physicians' satisfaction with their jobs and life as a whole. Design: Cross-sectional, mailed survey. Study population: Family physicians practicing in rural communities eligible for British Columbia's Northern and Isolation Allowance. Main measures: Demographics, Domain satisfaction, Maslach Burnout Inventory, Beck Depression Inventory, and Life Satisfaction. Results: Stepwise multiple regressions reveal the greatest predicators of rural physician overall life satisfaction are satisfaction with jobs, personal relationships, health, finances, and absence of depression. These predictors account for 70% of the variation in rural physician overall life satisfaction. The greatest predictors of rural physician satisfaction with jobs and satisfaction with current place of residence/practice, on-call shifts, personal accomplishments, and absence of emotional exhaustion. The predictors account for 44% of the variation in rural physician job satisfaction.