To assess the extent to which consumers of adult retail stores present "teachable moments" that could be used for sexuality education, data were analyzed from 273 employees of adult retail stores in 61 U.S. cities. Participants reported on the frequency with which they were asked questions related to disease prevention, pregnancy prevention, or sexual enhancement. Additionally, participants provided 806 questions that they were personally most frequently asked. Findings indicate that they most frequently receive questions about adult media products, sexual toys, and lubricants; further, questions are most often framed within the context of sexual enhancement. By reconceptualizing these questions and the potential responses of employees, sexuality educators may realize that there is a unique opportunity for engaging with this industry to enhance the availability of accurate information to sexually active or interested adults. (Contains 3 tables.)