In this article, I offer the notion of alignment, a human resources framework, as a conceptual tool for better informing the development of mentoring programming and policy in higher education. Alignment accounts for both individual and organizational factors as means for providing the necessary connections among human resources and organizational policies and outcomes. The three types of alignment: "Vertical" (connection between people strategy and business goals), "horizontal" (connection among individual HR policy areas), and "implementation" (the degree to which action is taken to put the people strategy into effect) have the potential to improve the efficacy of mentorships, the contextual factors that influences them, and the intended outcomes of these relationships.