Children and adolescents worldwide experience a variety of adversities that have the potential to disrupt typical development. However, some of these individuals exhibit resilience, evidencing normal development in the face of adversity. Here we review research on these constructs of risk, adversity, and resilience; synthesize international research on factors that may serve to protect children and adolescents from the negative effects of adversity at the individual, family, school, community, and cultural levels; and provide future implications for research on this topic, highlighting the unique contributions of the subsequent articles in this special issue, each of which contributes to an understanding of resilience processes in non-Western populations. Although some general trends in resilience and protection may extend beyond national borders, resilience is also strongly influenced by culture and context; therefore, it is important to advance a research agenda that recognizes the unique protective influences within and across cultural contexts.