In this article, we review the risk and protective factors for adolescent smoking, as well as current research on evidence-based practices. The relevance of structured expressive therapy in meeting the maturational and emotional needs of at-risk and delinquent adolescents, and the multicultural context of adolescents in Singapore's Asian society are also explored. We present a framework for an evidence-based psychoeducational structured expressive therapy group work model which was pioneered in Singapore residential rehabilitation programs and high schools under the auspices of CARE Singapore. (Contains 3 tables.)